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Journal: bioRxiv
Article Title: Collagen type I promotes pancreatic tumor growth and limits immune cell infiltration
doi: 10.64898/2026.01.09.698616
Figure Lengend Snippet: (A) Schematic representation of the tamoxifen-inducible Col1a1 KO mouse model. Created with Biorender.com . (B) Mean tumor growth curves of wildtype littermate control and non-tamoxifen-treated Col1a1 KO mice. (C) Col1a1 gene expression in tumors from control and non-tamoxifen-treated Col1a1 KO mice. (B-C) n = 7-8 mice per group. (D) Mean tumor growth curves of tamoxifen-treated control and Col1a1 KO mice. (E) Col1a1 gene expression in tumors from tamoxifen-treated control and Col1a1 KO mice. (D-E) n = 8-9 mice per group. (F-G) Serum levels of the collagen formation product PRO-C1 (F) and the collagen degradation product C1M (G) from tamoxifen-treated control and Col1a1 KO mice. Some samples were below the lower limit of detection (2.2ng/mL for PRO-C1 and 6.38 for C1M). (H-I) Quantification (left) and representative images (right) of picrosirius red (PSR) (H) and Masson’s Trichrome (I) staining of Pan02 tumors from tamoxifen-treated control and Col1a1 KO mice. Each data point represents the average of 10 random squares per image. Statistical significance was assessed using the two-tailed student’s t-test (C, E-I) and two-way ANOVA with Bonferroni correction (D) . Bars represent mean ± SEM (B,D) or SD (C, E-I) . * p <0.05, ** p <0.01, *** p <0.001.
Article Snippet: Sections were stained with
Techniques: Control, Gene Expression, Staining, Two Tailed Test